Zolpidem Oral Spray

Pronunciation: zole-PI-dem
Generic Name: Zolpidem
Brand Name: Zolpimist

Zolpidem Oral Spray is used for:

Short-term treatment of insomnia (trouble falling asleep).

Zolpidem Oral Spray is a sedative-hypnotic, or sleep medicine. It works by helping to increase certain natural chemicals in the brain that cause sleep.

Do NOT use Zolpidem Oral Spray if:

• you are allergic to any ingredient in Zolpidem Oral Spray


• you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zolpidem Oral Spray:

Some medical conditions may interact with Zolpidem Oral Spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have kidney or liver problems, lung or breathing problems (eg, chronic obstructive pulmonary disease [COPD], sleep apnea), myasthenia gravis, metabolism problems, heart or blood pressure problems, or very poor health


• if you have a history of mood or mental problems (eg, depression), suicidal thoughts or behaviors, or alcohol or substance abuse or addiction


• if you are a child or teenager with a history of attention deficit hyperactivity disorder (ADHD)


• if you take other medicines to help you sleep (eg, triazolam, zaleplon)

Some MEDICINES MAY INTERACT with Zolpidem Oral Spray. Tell your health care provider if you are taking any other medicines, especially any of the following:

• HIV protease inhibitors (eg, ritonavir), ketoconazole, or sodium oxybate (GHB) because they may increase the risk of Zolpidem Oral Spray's side effects


• Rifampin because it may decrease Zolpidem Oral Spray's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zolpidem Oral Spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zolpidem Oral Spray:

Use Zolpidem Oral Spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zolpidem Oral Spray comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zolpidem Oral Spray refilled.


• Take Zolpidem Oral Spray by mouth on an empty stomach at least 2 hours after a meal.


• Zolpidem Oral Spray works very quickly; use Zolpidem Oral Spray right before going to sleep.


• Use Zolpidem Oral Spray only when you are able to get a full night's sleep (7 to 8 hours).


• Zolpidem Oral Spray needs to be primed before you use it for the first time. To prime Zolpidem Oral Spray, remove the child-resistant cap and inner clear protective cap. Point the spray opening away from your face and other people. Fully press down on the pump with your finger. Release and let the pump return to starting position. Repeat these steps 4 more times. You should see a fine spray. The medicine is now ready to use.


• If Zolpidem Oral Spray has not been used within the last 14 days, reprime before using by pressing down 1 time on the pump.


• To use Zolpidem Oral Spray, open your mouth and hold the container upright with the spray opening pointed directly into your mouth. Press all the way down on the pump and let the medicine spray directly into your mouth over your tongue. If your dose requires a second spray, repeat these steps. Keep the spray away from your eyes. Put the clear protective cap and child-resistant cap back on after each use.


• Discard Zolpidem Oral Spray after 60 sprays have been used.


• If you miss a dose of Zolpidem Oral Spray, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Do not take more than your total daily dose in any 24-hour period.

Ask your health care provider any questions you may have about how to use Zolpidem Oral Spray.

Important safety information:

• Zolpidem Oral Spray may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Zolpidem Oral Spray with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zolpidem Oral Spray; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• When you first start taking Zolpidem Oral Spray, it may have a "carryover" effect on you the next day. Use extreme care while doing anything that requires complete alertness (eg, driving a car).


• Zolpidem Oral Spray is usually used only for a short period of time. If your symptoms do not get better within 7 to 10 days or if they get worse, check with your doctor.


• Sleep medicines may cause a special type of memory loss or amnesia. To prevent memory problems, be sure to use Zolpidem Oral Spray only when you are able to get a full night's sleep (7 to 8 hours) before you need to be active again. Be sure to talk to your health care provider if you think you are having memory problems.


• Some patients taking Zolpidem Oral Spray have performed certain activities while they were not fully awake. These have included sleep-driving, making and eating food, making phone calls, and having sex. Patients often do not remember these events after they happen. Such an event may be more likely to occur if you use a high dose of Zolpidem Oral Spray. It may also be more likely if you drink alcohol or take other medicines that may cause drowsiness while you use Zolpidem Oral Spray. Tell your doctor right away if such an event happens to you.


• Use Zolpidem Oral Spray with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness or drowsiness.


• Zolpidem Oral Spray should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. Children may be more sensitive to Zolpidem Oral Spray's side effects, especially dizziness, headache, and hallucinations.


• PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zolpidem Oral Spray while you are pregnant. Zolpidem Oral Spray may cause prolonged sleep or severe breathing problems in the newborn if you take it during the last weeks of pregnancy, especially if you take it with certain medicines. Zolpidem Oral Spray is found in breast milk. If you are or will be breast-feeding while you use Zolpidem Oral Spray, check with your doctor. Discuss any possible risks to your baby.

When sleep medicines are used every night for more than a few weeks, they may lose their effectiveness to help you sleep. This is known as TOLERANCE. Sleep medicines should usually be used only for short periods of time, such as a few days, and generally no longer than 1 or 2 weeks. If your sleep problems continue, contact your doctor.

When used for longer than a few weeks or at high doses, some people develop a need to continue taking Zolpidem Oral Spray. This is known as DEPENDENCE or addiction. Be sure to tell your doctor if you have been dependent on alcohol, prescription medicines, or street drugs in the past.

If you stop taking Zolpidem Oral Spray suddenly, you may have WITHDRAWAL symptoms. This may include unpleasant feelings. In more severe cases, you may have stomach and muscle cramps, vomiting, sweating, and shakiness. Seizures may rarely occur. If you take Zolpidem Oral Spray for more than 1 to 2 weeks, do not stop taking it without talking to your doctor.

Possible side effects of Zolpidem Oral Spray:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness (including daytime drowsiness); "drugged" feeling; dry mouth; headache; nausea; nose or throat irritation; sluggishness; stomach upset; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, eyes, throat, or tongue; throat closing; unusual hoarseness; severe nausea or vomiting); abnormal thinking; behavior changes; chest pain; confusion; decreased coordination; difficulty swallowing or breathing; fainting; fast or irregular heartbeat; hallucinations; memory problems (eg, memory loss); mental or mood changes (eg, aggression, agitation, anxiety); new or worsening depression; severe dizziness or lightheadedness; shortness of breath; suicidal thoughts or actions; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Zolpidem side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe drowsiness or coma.

Proper storage of Zolpidem Oral Spray:

Store Zolpidem Oral Spray at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Avoid prolonged storage above 86 degrees F (30 degrees C). Store Zolpidem Oral Spray upright and away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Zolpidem Oral Spray out of the reach of children and away from pets.

General information:

• If you have any questions about Zolpidem Oral Spray, please talk with your doctor, pharmacist, or other health care provider.


• Zolpidem Oral Spray is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is summary only. It does not contain all information about Zolpidem Oral Spray. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Zolpidem resources

• Zolpidem Side Effects (in more detail)
• Zolpidem Use in Pregnancy & Breastfeeding
• Drug Images
• Zolpidem Drug Interactions
• Zolpidem Support Group
• 304 Reviews for Zolpidem - Add your own review/rating

Compare Zolpidem with other medications

• Insomnia

Zostrix Cream

Pronunciation: kap-SAY-sin
Generic Name: Capsaicin
Brand Name: Examples include Capzasin-P and Zostrix

Zostrix Cream is used for:

Temporary relief of muscle and joint pain associated with arthritis, simple backaches, sprains, strains, and bruises. It may also be used for other conditions as determined by your doctor.

Zostrix Cream is a topical analgesic. Exactly how it works is unknown, but it is thought to decrease the amount of a certain substance (substance P) that transmits pain in the body.

Do NOT use Zostrix Cream if:

• you are allergic to any ingredient in Zostrix Cream

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zostrix Cream:

Some medical conditions may interact with Zostrix Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have an open wound or damaged, broken, or irritated skin

Some MEDICINES MAY INTERACT with Zostrix Cream. Because little, if any, of Zostrix Cream is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Zostrix Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zostrix Cream:

Use Zostrix Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Zostrix Cream. Talk to your pharmacist if you have questions about this information.


• Apply just enough medicine to cover the affected area. Gently massage the medicine into skin until it disappears.


• Wash your hands with soap and water immediately after using Zostrix Cream unless your hands are part of the treated area.


• If you are using Zostrix Cream on your hands, allow 30 minutes for the medicine to absorb before washing. During this time, avoid touching damaged or irritated skin, contact lenses, or your eyes, nose, mouth, or other mucous membranes. Wash hands after 30 minutes.


• Do not apply to wounds or damaged, broken (open), or irritated skin.


• Do not bandage or wrap the affected area.


• Do not use Zostrix Cream with a heating pad.


• Do not expose the treated area to heat or direct sunlight. Warm or hot water or sunlight may increase the likelihood of burning or itching. Do not use Zostrix Cream immediately after bathing, swimming, using a hot tub, sunbathing, or exposure to heat.


• If you miss a dose of Zostrix Cream, use it as soon as you remember. Continue to use it as directed by your doctor or on the package label.

Ask your health care provider any questions you may have about how to use Zostrix Cream.

Important safety information:

• For external use only. Avoid contact with the eyes, nose, and mouth. If Zostrix Cream gets into your eyes, rinse immediately with cool water.


• Do not use more than the recommended dose, use for longer than prescribed, or use large amounts of Zostrix Cream without checking with your doctor.


• Do not inhale any residue from Zostrix Cream after it has dried. Coughing, sneezing, or throat or respiratory irritation may occur.


• Zostrix Cream may be harmful if swallowed. If you may have taken Zostrix Cream by mouth, contact your local poison control center or emergency room immediately.


• If condition worsens, or if symptoms persists for more than 7 days or clear up and occur again within a few days, stop use of this product and contact your health care provider.


• If redness is present or if irritation develops, check with your doctor before using any more of Zostrix Cream.


• If severe burning or itching occurs, remove product by thoroughly washing the area with soap and cold water.


• Zostrix Cream should not be used in CHILDREN younger than 18 years old without checking with the child's doctor; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zostrix Cream while you are pregnant. It is not known if Zostrix Cream is found in breast milk. If you are or will be breast-feeding while you use Zostrix Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zostrix Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Temporary burning or stinging at the application site that usually disappears in a few days.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty breathing or swallowing; irritation, redness, blistering, or severe or persistent burning at the application site.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Zostrix side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Zostrix Cream may be harmful if swallowed.

Proper storage of Zostrix Cream:

Store Zostrix Cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Close cap tightly after use. Do not store in the bathroom. Keep Zostrix Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Zostrix Cream, please talk with your doctor, pharmacist, or other health care provider.


• Zostrix Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Zostrix Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Zostrix resources

• Zostrix Side Effects (in more detail)
• Zostrix Use in Pregnancy & Breastfeeding
• Zostrix Drug Interactions
• Zostrix Support Group
• 1 Review for Zostrix - Add your own review/rating

Compare Zostrix with other medications

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• Osteoarthritis
• Pain
• Persisting Pain, Shingles

Zonegran

Generic Name: zonisamide (Oral route)

zoe-NIS-a-mide

Commonly used brand name(s)

In the U.S.

• Zonegran

Available Dosage Forms:

• Capsule


• Tablet

Therapeutic Class: Anticonvulsant

Chemical Class: Sulfonamide

Uses For Zonegran

Zonisamide is used together with other medicines to control partial seizures (convulsions) in the treatment of epilepsy. This medicine is an anticonvulsant that works in the brain tissue to stop seizures.

This medicine is available only with your doctor's prescription.

Before Using Zonegran

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of zonisamide in children below 16 years of age. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of zonisamide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of zonisamide in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients receiving zonisamide.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Ketorolac


• Metformin


• Naproxen

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Ginkgo

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood or bone marrow problems (e.g., agranulocytosis, aplastic anemia) or


• Depression, history of—Use with caution. May make these conditions worse.

• Kidney disease or


• Liver disease—Use with caution. Effects may be increased because of slower removal of the medicine from the body.

Proper Use of Zonegran

Take this medicine only as directed by your doctor to help your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a medication guide and a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Zonisamide may be taken with or without food, on a full or empty stomach. Swallow the capsule whole. Do not break, crush, or chew it.

It is important that you drink extra water every day while you take zonisamide to help prevent kidney stones.

This medicine will be used together with other seizure medicines. Keep using all of your medicines unless your doctor tells you to stop.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (capsules):
  
  • For seizures:
    
    • Adults and teenagers 16 years of age and older—At first, 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day.
    
    
    • Children and teenagers younger than 16 years of age—Use and dose must be determined by the doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Zonegran

It is very important that your doctor check your progress at regular visits to see if the medicine is working properly. Blood tests may be needed to check for unwanted effects.

It is important to tell your doctor if you become pregnant. Your doctor may want you to join a pregnancy registry for pregnant patients taking a seizure medicine.

This medicine may cause some people to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicines or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you are taking this medicine.

Contact your doctor immediately if you develop a skin rash, fever, sore throat, sores in your mouth, easy bruising, severe muscle pain or weakness, or worsening of your seizures.

Check with your doctor right away if you have sudden back pain, abdominal or stomach pain, pain while urinating, or bloody or dark urine. These may be symptoms of kidney stones.

Serious skin reactions can occur with this medicine. Stop using this medicine and check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, or loosening of the skin; chills; cough; diarrhea; itching; joint or muscle pain; red skin lesions, often with a purple center; sores, ulcers, or white spots in the mouth or on the lips; or unusual tiredness or weakness.

This medicine may make you sweat less, which causes your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are taking this medicine. Overheating may result in heat stroke. Also, hot baths or saunas may make you dizzy or faint while you are taking this medicine.

Do not stop taking zonisamide without first checking with your doctor. Stopping the medicine suddenly may cause your seizures to return or to occur more often. Your doctor may want you to gradually reduce the amount of medicine you are taking before stopping it completely.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines, and herbal or vitamin supplements.

Zonegran Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Discouragement


• feeling sad or empty


• irritability


• lack of appetite


• loss of interest or pleasure


• mood or mental changes


• shakiness or unsteady walking


• tiredness


• trouble with concentrating


• trouble with sleeping

Less common

• Agitation


• bruising


• delusions


• hallucinations


• large, flat blue or purplish patches on the skin


• rash

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Difficult or labored breathing


• faintness


• loss of consciousness


• slow or irregular heartbeat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach pain


• anxiety


• difficulty with memory


• dizziness


• double vision


• headache


• loss of appetite


• nausea


• restlessness


• sleepiness


• sleeplessness


• unusual drowsiness


• unusual tiredness or weakness

Less common

• Aching muscles or joints


• acid or sour stomach


• bad, unusual, or unpleasant taste in the mouth


• belching


• change in taste


• chills


• constipation


• diarrhea


• difficulty with speaking


• difficulty with thinking


• dry mouth


• fever


• general ill feeling


• headache


• heartburn


• indigestion


• mental slowness


• nervousness


• runny or stuffy nose


• sneezing


• tingling, burning, or prickly feelings on the skin


• uncontrolled, back and forth, or rolling eye movements


• weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Zonegran side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Zonegran resources

• Zonegran Side Effects (in more detail)
• Zonegran Use in Pregnancy & Breastfeeding
• Drug Images
• Zonegran Drug Interactions
• Zonegran Support Group
• 18 Reviews for Zonegran - Add your own review/rating

• Zonegran Prescribing Information (FDA)


• Zonegran Consumer Overview


• Zonegran Monograph (AHFS DI)


• Zonegran MedFacts Consumer Leaflet (Wolters Kluwer)


• Zonisamide Professional Patient Advice (Wolters Kluwer)

Compare Zonegran with other medications

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Zostrix

Generic Name: capsaicin topical (kap SAY sin TOP i kal)

Brand Names: Axsain, Capsicum Oleoresin, Capsin, Capzasin Back and Body, Capzasin Quick Relief, Capzasin-HP, Capzasin-P, Castiva Warming, Dolorac, Icy Hot PM, Icy Hot with Capsaicin, Menthac Arthritis Cream with Capsaicin, Qutenza, Salonpas Gel-Patch, Salonpas Pain Patch with Capsaicin, Sloan's Liniment, Trixaicin, Trixaicin HP, Zostrix, Zostrix Diabetic Foot Pain, Zostrix Foot Pain, Zostrix Neuropathy, Zostrix Sports, Zostrix-HP

What is Zostrix (capsaicin topical)?

Capsaicin is the active ingredient in chili peppers that makes them hot. Capsaicin is used in medicated creams and lotions to relieve muscle or joint pain.

Capsaicin used on the body causes a sensation of heat that activates certain nerve cells. With regular use of capsaicin, this heating effect reduces the amount of substance P, a chemical that acts as a pain messenger in the body.

Capsaicin topical is used for temporary relief of muscle or joint pain caused by strains, sprains, arthritis, bruising, or backaches. Capsaicin topical is also used to treat nerve pain (neuralgia) in people who have had herpes zoster, or "shingles."

Capsaicin topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Zostrix (capsaicin topical)?

Do not use this medication if you are allergic to chili peppers, or if you have ever had an allergic reaction to capsaicin topical.

Ask a doctor or pharmacist about using capsaicin topical if you have any allergies or serious medical conditions. Do not use this medication on anyone younger than 18 years old without the advice of a doctor.

Capsaicin can cause a burning sensation, which is usually mild and should lessen over time with continued use. If the burning sensation causes significant discomfort, wash the treated skin area with soap and cool water. Stop using the medication and call your doctor if you have severe burning or redness where the medicine was applied.

Avoid getting capsaicin topical in your mouth or eyes or near your nose.

Do not apply to open wounds or irritated skin, and avoid getting the medicine on contact lenses, dentures, and other items that come into contact with sensitive areas of your body.

Seek emergency medical attention if you think you have used too much of this medicine, or if anyone has accidentally swallowed it. Accidental swallowing of capsaicin can cause problems with swallowing or breathing.

It may take up to 2 weeks of using this medicine regularly before your symptoms improve. For best results, keep using the medication as directed.

Call your doctor if your pain does not improve after using this medication for 7 days, or if your symptoms get worse or get better and then come back in a few days.

What should I discuss with my healthcare provider before using Zostrix (capsaicin topical)?

Do not use this medication if you are allergic to chili peppers, or if you have ever had an allergic reaction to capsaicin topical.

Ask a doctor or pharmacist about using capsaicin topical if you have any allergies (especially to plants), or if you have a serious medical condition.

It is not known whether capsaicin topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether capsaicin topical passes into breast milk or if it could harm a nursing baby. Do not apply capsaicin topical to your breast area if you are breast-feeding a baby. Do not use this medication on anyone younger than 18 years old without the advice of a doctor.

How should I use Zostrix (capsaicin topical)?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

Capsaicin can cause a burning sensation wherever it is applied. This sensation is usually mild and should gradually lessen over time with continued regular use of the medicine.

Do not apply capsaicin topical to open wounds, or to skin that is sunburned, windburned, dry, chapped, or otherwise irritated. Do not get this medication in your mouth or eyes, or near your nose where you might inhale it. If it does get into any of these areas, rinse thoroughly with water.

Also avoid getting this medication on contact lenses, dentures, and other items that come into contact with sensitive areas of your body.

To keep the medication from getting on your fingers when you apply it, you may use a rubber glove, finger cot, cotton ball, or clean tissue to apply the medicine.

Make sure your skin is clean and dry before you apply capsaicin topical.

When using capsaicin topical cream or lotion, apply a thin layer to the affected area and rub in gently until completely absorbed.

To use capsaicin topical liquid or stick, uncap the applicator and press it firmly on your skin to apply the medication. Massage gently onto the affected are until completely absorbed.

Capsaicin topical may be used up to 4 times daily or as directed on the medicine label.

To apply a capsaicin topical patch, remove the liner and apply the patch to your skin over the area of pain. Press the edges firmly into place. Remove the patch and apply a new patch 1 or 2 times daily if needed.

Wash your hands with soap and water immediately after applying capsaicin topical or handling the topical patch. If you have applied the medicine to your hands or fingers to treat pain in those areas, wait at least 30 minutes before washing your hands. Do not cover treated skin with a bandage or heating pad, which can increase the burning sensation. You may cover the skin with clothing.

Avoid taking a bath or shower within 1 hour before or after you apply capsaicin topical to your skin. Also avoid swimming or vigorous exercise. Warm water or perspiration can increase the burning sensation caused by capsaicin.

If the burning sensation caused by capsaicin is painful or causes significant discomfort, wash the treated skin area with soap and cool water.

It may take up to 2 weeks of using this medicine regularly before your symptoms improve. For best results, keep using the medication as directed. Pain relief should occur gradually as the substance P in your body is decreased in the nerve cells.

Call your doctor if your pain does not improve after using this medication for 7 days, or if your symptoms get worse or get better and then come back in a few days. Store capsaicin topical at room temperature away from moisture and heat, in a place where children and pets cannot get to it.

Capsaicin topical liquid is flammable. Do not use or store near fire or open flame.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not apply capsaicin more than 4 times in one day, or use extra medicine to make up a missed dose .

A missed dose of capsaicin topical will not cause harm but may make the medication less effective reducing substance P and relieving your pain.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222, especially if anyone has accidentally swallowed it.

Accidental swallowing of capsaicin can cause severe burning in or around the mouth, watery eyes, runny nose, and trouble swallowing or breathing.

Applying too much capsaicin topical to the skin can cause severe burning or redness.

What should I avoid while using Zostrix (capsaicin topical)?

Avoid inhaling the odor or dried residue of capsaicin topical. Inhaling capsaicin can cause coughing, sneezing, or watery eyes, and can irritate your throat or lungs.

Avoid touching your eyes, mouth, nose, genitals, or rectum until the medication has been washed off your hands. Also avoid handling food while the medication is still on your hands.

Avoid exposing treated skin to sunlight, sunlamps, tanning beds, or a hot tub. Capsaicin can cause a burning sensation that may be made worse by heat.

Do not use other medicated skin products, including muscle pain creams or lotions, on areas where you have applied capsaicin, unless your doctor has told you to.

Zostrix (capsaicin topical) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using capsaicin topical and call your doctor at once if you have a serious side effect such as:

• 
  

  severe burning or irritation where the medicine was applied;

  
  


• 
  

  skin redness where the medicine was applied; or

  
  


• 
  

  trouble breathing or swallowing (after accidental inhalation of capsaicin odor or dried residue).

  
  

Less serious side effects may include a mild burning sensation that can last for several hours or days, especially after your first use of capsaicin topical.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Zostrix (capsaicin topical)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied capsaicin. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Zostrix resources

• Zostrix Side Effects (in more detail)
• Zostrix Use in Pregnancy & Breastfeeding
• Zostrix Drug Interactions
• Zostrix Support Group
• 1 Review for Zostrix - Add your own review/rating

• Zostrix Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Zostrix Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Axsain Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Qutenza Prescribing Information (FDA)


• Qutenza Patch MedFacts Consumer Leaflet (Wolters Kluwer)


• Qutenza Consumer Overview

Compare Zostrix with other medications

• Diabetic Nerve Damage
• Osteoarthritis
• Pain
• Persisting Pain, Shingles

Where can I get more information?

• Your pharmacist can provide more information about capsaicin topical.

See also: Zostrix side effects (in more detail)

Zonisamide

Pronunciation: zoe-NIS-a-mide
Generic Name: Zonisamide
Brand Name: Zonegran

Zonisamide is used for:

Treating certain types of seizures (partial seizures) in patients with epilepsy. It is used along with other medicines. It may also be used for other conditions as determined by your doctor.

Zonisamide is an anticonvulsant. Exactly how Zonisamide works is not known.

Do NOT use Zonisamide if:

• you are allergic to any ingredient in Zonisamide or to a sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, or valdecoxib


• you have kidney failure

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zonisamide:

Some medical conditions may interact with Zonisamide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances (including tartrazine)


• if you are allergic to aspirin


• if you have a history of status epilepticus (eg, long periods of continuous seizure activity or a series of seizures without a full return to consciousness)


• if you have a history of liver or kidney problems, kidney stones, lung or breathing problems, mental or mood problems (eg, depression), or suicidal thoughts or actions


• if you have a skin rash


• if you have diarrhea, will be having surgery, or are on a ketogenic diet

Some MEDICINES MAY INTERACT with Zonisamide. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticholinergics (eg, benztropine) or carbonic anhydrase inhibitors (eg, acetazolamide) because the risk of heatstroke or high blood acid levels may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zonisamide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zonisamide:

Use Zonisamide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zonisamide comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zonisamide refilled.


• Take Zonisamide by mouth with or without food.


• Swallow Zonisamide whole. Do not break, crush, or chew before swallowing.


• Drink plenty of liquids (6 to 8 glasses of water per day) while taking Zonisamide to help prevent kidney stones.


• Do not suddenly stop taking Zonisamide. Suddenly stopping Zonisamide may cause seizures to occur more often. If you need to stop Zonisamide, your doctor will gradually lower your dose.


• If you miss a dose of Zonisamide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zonisamide.

Important safety information:

• Zonisamide may cause dizziness, drowsiness, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use Zonisamide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Zonisamide may reduce sweating, which could increase the risk of heat stroke, especially in children. The risk is greater in hot weather and/or during vigorous exercise. Drink plenty of fluids. Dress lightly while in hot climates or when exercising. Check carefully for signs of decreased sweating. If this occurs, promptly seek cooler or air-conditioned shelter and/or stop exercising. Seek medical attention right away if you have an unexplained fever, mental or mood changes, headache, or dizziness.


• Zonisamide may cause high blood acid levels (metabolic acidosis). The risk may be greater in children and in patients with kidney problems, status epilepticus, severe breathing problems, or diarrhea. It may also be greater in patients who are taking certain other medicines (eg, acetazolamide), will be having surgery, or are on a ketogenic diet. Over a period of time, metabolic acidosis may cause kidney problems, bone problems, or decreased growth in children. Contact your doctor immediately if you experience fast breathing, unusual weakness or fatigue, sluggishness, fainting, persistent loss of appetite, or irregular heartbeat.


• Patients who take Zonisamide may be at increased risk of suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Zonisamide closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


• Contact your doctor right away if your seizures worsen or if you develop a skin rash.


• Tell your doctor or dentist that you take Zonisamide before you receive any medical or dental care, emergency care, or surgery.


• Carry an ID card at all times that says you take Zonisamide.


• This product may contain tartrazine dye (FD&C Yellow No. 5). This may cause an allergic reaction in some patients. If you have ever had an allergic reaction to tartrazine, ask your pharmacist if your product has tartrazine in it.


• Women who take Zonisamide should use effective birth control while using Zonisamide.


• Lab tests, including kidney function or blood bicarbonate levels, may be performed while you use Zonisamide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Zonisamide with caution in the ELDERLY; they may be more sensitive to its effects.


• Zonisamide should be used with extreme caution in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed. CHILDREN may be at a higher risk of heatstroke, kidney stones, decreased growth, and metabolic acidosis.


• PREGNANCY AND BREAST-FEEDING: Zonisamide may cause harm to the fetus. Do not become pregnant while you are using it. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zonisamide while you are pregnant. It is not known if Zonisamide is found in breast milk. If you are or will be breast-feeding while you use Zonisamide, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zonisamide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; diarrhea; dizziness; drowsiness; flu-like symptoms; headache; irritability; loss of appetite; nausea; stomach upset; tiredness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bone pain; change in the amount of urine produced; confusion; dark or bloody urine; decreased sweating; double vision or other vision problems; fainting; fast breathing; fast, slow, or irregular heartbeat; fever, chills, cough, or sore throat; loss of coordination; memory problems; mouth sores; new or worsening mental or mood changes (eg, depression, agitation, anxiety, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, inability to sit still); new or worsening seizures; painful urination; persistent loss of appetite; red, swollen, blistered, or peeling skin; severe muscle pain or weakness; severe or persistent drowsiness; sluggishness; sudden stomach or back pain; suicidal thoughts or actions; swelling of the hands, ankles, or feet; tremor; trouble speaking or other speech problems; trouble thinking or concentrating; unusual bruising or bleeding; unusual eye movements; unusual or disturbing thoughts; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Zonisamide side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include difficult, slow, or shallow breathing; severe or persistent dizziness; slow heartbeat; weakness.

Proper storage of Zonisamide:

Store Zonisamide at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zonisamide out of the reach of children and away from pets.

General information:

• If you have any questions about Zonisamide, please talk with your doctor, pharmacist, or other health care provider.


• Zonisamide is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Zonisamide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Zonisamide resources

• Zonisamide Side Effects (in more detail)
• Zonisamide Use in Pregnancy & Breastfeeding
• Drug Images
• Zonisamide Drug Interactions
• Zonisamide Support Group
• 20 Reviews for Zonisamide - Add your own review/rating

• Zonisamide Professional Patient Advice (Wolters Kluwer)


• Zonisamide Monograph (AHFS DI)


• zonisamide Advanced Consumer (Micromedex) - Includes Dosage Information


• Zonegran Prescribing Information (FDA)


• Zonegran Consumer Overview

Compare Zonisamide with other medications

• Benign Essential Tremor
• Migraine Prevention
• Parkinsonian Tremor
• Seizures

Zomig Spray

Pronunciation: ZOLE-mi-TRIP-tan
Generic Name: Zolmitriptan
Brand Name: Zomig

Zomig Spray is used for:

Treating migraine headaches with or without aura (flashing lights, wavy lines, dark spots) in adults. It is not intended to prevent migraines.

Zomig Spray is a serotonin 5-HT₁ receptor agonist ("triptan"). It works by narrowing blood vessels in the brain, which helps to relieve migraines.

Do NOT use Zomig Spray if:

• you are allergic to any ingredient in Zomig Spray


• you have certain types of irregular heartbeat (eg, symptomatic Wolff-Parkinson-White syndrome)


• you have a history of ischemic heart disease (eg, angina, a heart attack), coronary artery disease (CAD), other moderate to severe heart problems, brain blood vessel disease (eg, a stroke, a transient ischemic attack), or other blood vessel disease (eg, Raynaud syndrome, ischemic bowel disease)


• you have uncontrolled high blood pressure


• you have certain types of migraines (eg, hemiplegic, basilar)


• you have used an ergot alkaloid (eg, ergotamine) or another "triptan" migraine medicine in the last 24 hours


• you are currently taking sibutramine


• you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zomig Spray:

Some medical conditions may interact with Zomig Spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have history of liver or kidney problems, seizures (eg epilepsy), heart problems (eg, irregular heartbeat), or other types of headaches (eg, cluster headaches)


• if you have shortness of breath, chest pain, or a history of high blood pressure, a heart attack, a stroke, high cholesterol, diabetes, or smoking


• if you are a woman who is past menopause


• if you are a man who is over 40 years old


• if you are very overweight


• if a family member has had heart disease or a stroke

Some MEDICINES MAY INTERACT with Zomig Spray. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), or sibutramine because the risk of a serious side effect called serotonin syndrome may be increased. Symptoms of serotonin syndrome may include mental or mood changes, hallucinations, fast heartbeat, fever, loss of coordination, muscle spasms, increased sweating, nausea, vomiting, or diarrhea


• Cimetidine or MAOIs (eg, phenelzine) because they may increase the risk of Zomig Spray's side effects


• Ergot derivatives (eg, dihydroergotamine, methysergide) or other serotonin 5-HT₁ receptor agonists (eg, eletriptan, rizatriptan) because the risk of their side effects may be increased by Zomig Spray

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zomig Spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zomig Spray:

Use Zomig Spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Zomig Spray. Talk to your pharmacist if you have questions about this information.


• It is best to use Zomig Spray as soon as you notice the headache symptoms of a migraine attack.


• Avoid spraying Zomig Spray into the eyes.


• The protective cap must not be removed from Zomig Spray until you are ready to use it.


• Do NOT test the spray before use.


• Gently blow your nose, then sit down and tilt your head back slightly. Spray the prescribed dose into 1 nostril as directed. Breathe gently through your mouth for 5 to 10 seconds. You may feel liquid in your nose or the back of your throat. This is normal and will go away.


• If your migraine symptoms go away and then come back, you may take a second dose as directed by your doctor. Wait at least 2 hours between doses.


• If your symptoms do not get better after the first dose, do not take a second dose for the same attack. Contact your doctor.


• Do NOT take more than the amount prescribed by your doctor in a 24-hour period or treat more than 3 headaches within 30 days without checking with your doctor.


• If your medicine has expired, throw it away.


• If you miss a dose of Zomig Spray and you still have a headache, follow your doctor's dosing instructions. Contact your doctor if you are unsure of what to do if you miss a dose. Do NOT use Zomig Spray more often than prescribed. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Zomig Spray.

Important safety information:

• Zomig Spray may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Zomig Spray with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Overuse of Zomig Spray can cause your headache to become worse. Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor.


• Rarely, serious heart problems (eg, a heart attack, irregular heartbeat) have been reported within a few hours of using Zomig Spray. Contact your doctor at once if fast or irregular heartbeat; chest, jaw, or neck pain or numbness; numbness of an arm or leg; severe stomach pain, dizziness, or vomiting; fainting; or vision changes occur. Discuss any questions or concerns with your doctor.


• Serotonin syndrome is a possibly fatal syndrome that can be caused by Zomig Spray. Your risk may be greater if you take Zomig Spray with certain other medicines (eg, SSRIs, SNRIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.


• Zomig Spray should not be used to prevent or reduce the number of migraine headaches you have. If you have a headache that is different than your usual migraine headaches, check with your doctor before using Zomig Spray.


• Lab tests, including heart function, may be performed while you use Zomig Spray. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Zomig Spray with caution in the ELDERLY; they may be more sensitive to its effects.


• Zomig Spray should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zomig Spray while you are pregnant. It is not known if Zomig Spray is found in breast milk. If you are or will be breast-feeding while you use Zomig Spray, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zomig Spray:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning, numbness, or tingling of the skin; dizziness; drowsiness; dry mouth; feeling of heaviness or pressure; nausea; unusual taste; warm or hot sensation; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody diarrhea; chest pain; confusion; fainting; fast or irregular heartbeat; numbness or tingling of an arm or leg; one-sided weakness; pain, tightness, or pressure in the jaw, neck, or chest; severe headache, dizziness, or vomiting; severe stomach pain; shortness of breath; speech changes; very cold or blue fingers or toes; vision changes or loss of vision; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Zomig side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Symptoms may include unusual drowsiness.

Proper storage of Zomig Spray:

Store Zomig Spray at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zomig Spray out of the reach of children and away from pets.

General information:

• If you have any questions about Zomig Spray, please talk with your doctor, pharmacist, or other health care provider.


• Zomig Spray is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Zomig Spray. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Zomig resources

• Zomig Side Effects (in more detail)
• Zomig Use in Pregnancy & Breastfeeding
• Drug Images
• Zomig Drug Interactions
• Zomig Support Group
• 23 Reviews for Zomig - Add your own review/rating

Compare Zomig with other medications

• Cluster Headaches
• Cyclic Vomiting Syndrome
• Migraine

Zostavax

Pronunciation: ZOS-ter
Generic Name: Zoster Vaccine Live
Brand Name: Zostavax

Zostavax is used for:

Preventing herpes zoster (shingles) in certain patients.

Zostavax is an attenuated live vaccine for varicella-zoster virus (VZV). VZV is the virus that causes shingles. Zostavax works by helping your immune system protect you from VZV.

Do NOT use Zostavax if:

• you are allergic to any ingredient in Zostavax


• you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to gelatin or neomycin


• you have a history of a weakened immune system (eg, advanced HIV, AIDS, leukemia, lymphoma, cancer of the bone marrow or lymphatic system)


• you have active untreated tuberculosis (TB)


• you are or may be pregnant, or plan to become pregnant within 3 months after you receive Zostavax


• you take medicine that may weaken your immune system, including immunosuppressants (eg, cyclosporine) or high-dose corticosteroids (eg, prednisone)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zostavax:

Some medical conditions may interact with Zostavax. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have ever had an allergic reaction (eg, rash, hives, difficulty breathing, dizziness) to neomycin or another vaccine


• if you have ever had shingles


• if you have an infection, fever, or other current illness


• if you may be in close contact (eg, in the house or workplace) with anyone who has a weakened immune system, with a newborn infant, or with a woman who may be pregnant and has not had chickenpox or been vaccinated against chickenpox


• if you have recently had or are scheduled to have any other vaccine (eg, flu, pneumococcal)

Some MEDICINES MAY INTERACT with Zostavax. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Corticosteroids (eg, prednisone) or immunosuppressants (eg, cyclosporine) because they may decrease Zostavax's effectiveness or increase the risk of infection from Zostavax


• Pneumococcal vaccine because it may decrease Zostavax's effectiveness if given within 4 weeks of Zostavax

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zostavax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zostavax:

Use Zostavax as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Zostavax. Talk to your pharmacist if you have questions about this information.


• Zostavax is usually given as an injection at your doctor's office, hospital, or clinic.


• Do not use Zostavax if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• If you miss a dose of Zostavax, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Zostavax.

Important safety information:

• If you have a TB skin test within 8 months of receiving this vaccine, tell the doctor that you have received this vaccine.


• Zostavax is used to prevent shingles. It cannot be used to treat shingles once you have it.


• Zostavax may not prevent everyone who receives it from getting shingles. If you do get shingles after you receive Zostavax, it may help prevent nerve pain that can follow shingles in some people. Discuss any questions or concerns with your doctor.


• Rarely, people who receive Zostavax may spread the vaccine virus to other people. Tell your doctor if you have close contact with anyone who has a weakened immune system, with a newborn infant, or with a woman who may be pregnant and has not had chickenpox or been vaccinated against chickenpox. You will need to discuss the risk of spreading the vaccine virus to these people.


• Some patients who received Zostavax have reported fever, swollen glands near the injection site that lasted a few days to a few weeks, or joint or muscle pain. Check with your doctor if you experience side effects that persist or become bothersome. Discuss any questions or concerns with your doctor.


• Zostavax should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not use Zostavax if you are pregnant. Do not become pregnant for at least 3 months after you receive Zostavax. If you suspect that you could be pregnant or if you become pregnant within 3 months after receiving Zostavax, contact your doctor immediately. It is not known if Zostavax is found in breast milk. If you are or will be breast-feeding while you are using Zostavax, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zostavax:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; pain, swelling, redness, itching, warmth, and bruising at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Zostavax side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Zostavax:

Zostavax is usually handled and stored by a health care provider. If you are using Zostavax at home, store Zostavax as directed by your pharmacist or health care provider.

General information:

• If you have any questions about Zostavax, please talk with your doctor, pharmacist, or other health care provider.


• Zostavax is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Zostavax. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Zostavax resources

• Zostavax Side Effects (in more detail)
• Zostavax Use in Pregnancy & Breastfeeding
• Zostavax Drug Interactions
• Zostavax Support Group
• 3 Reviews for Zostavax - Add your own review/rating

• Zostavax Prescribing Information (FDA)


• Zostavax Consumer Overview


• Zostavax Monograph (AHFS DI)


• Zostavax Advanced Consumer (Micromedex) - Includes Dosage Information


• Zoster Vaccine Live Professional Patient Advice (Wolters Kluwer)

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